Comments by Bella Coronado

Comments by Bella Coronado Most recent public comments by Bella Coronado https://nowcomment.com/users/46128 Elevated levels of a protein called Kir4.1 (found in astrocyte cells). Kir4.1 promotes LHb neuron activity. https://nowcomment.com/documents/137479?scroll_to=1326603 https://nowcomment.com/documents/137479?scroll_to=1326603 Astrocyte cells: most abundant glial cells found in the brain associated with neuronal synapses. They regulate electrical impulses in the brain. Mon, 15 Apr 2019 16:06:42 -0400 Ketamine is super effective because the rapid blocking of NMDA receptors for glutamate stops the rapid firing. Usual antidepressants take months to be this effective https://nowcomment.com/documents/137479?scroll_to=1326602 https://nowcomment.com/documents/137479?scroll_to=1326602 Glutamate allows calcium to flood into the cells, which allows them to fire. Blocking glutamate receptors prevents the calcium from entering which prevents the cells from firing. Mon, 15 Apr 2019 16:03:57 -0400 Supposedly bursts of LHb activity cause depression, not constant firing. Bursts enhance communication with other regions. Researchers aren't exactly sure https://nowcomment.com/documents/137479?scroll_to=1326601 https://nowcomment.com/documents/137479?scroll_to=1326601 Mon, 15 Apr 2019 16:01:41 -0400 Over-active LHb could be the cause of depression. LHb is the basically the disappointment processing center, overactivity resulting in prolonged apathy and sadness. Found in animal studies. https://nowcomment.com/documents/137479?scroll_to=1326599 https://nowcomment.com/documents/137479?scroll_to=1326599 How do the studies on animals give viable research on humans? How do scientists recognize depressive behavior in organisms that don't have human consciousness? What is depressive behavior in animals? Mon, 15 Apr 2019 16:00:02 -0400 Ketamine interacts with glutamate, promotes growth of other neural connections. Glutamate is usually associated with plasticity rather than mood. Usual antidepressants work with serotonin. https://nowcomment.com/documents/137479?scroll_to=1326598 https://nowcomment.com/documents/137479?scroll_to=1326598 Mon, 15 Apr 2019 15:57:25 -0400 Depression may be caused by pattern in lateral habenula (LHb)- ketamine blocks the pattern. Found in studies on rats https://nowcomment.com/documents/137479?scroll_to=1326597 https://nowcomment.com/documents/137479?scroll_to=1326597 Mon, 15 Apr 2019 15:55:37 -0400 This is a good start, but I think we're at a point in time when its no longer acceptable to be just tolerant. I think we should be passing bills to make it illegal and punishable to discriminate at all based on gender. https://nowcomment.com/documents/136597?scroll_to=1323462 https://nowcomment.com/documents/136597?scroll_to=1323462 Thu, 11 Apr 2019 13:06:27 -0400 Its important to note that gender is not a physical trait, rather a psychological/social identity https://nowcomment.com/documents/136597?scroll_to=1323460 https://nowcomment.com/documents/136597?scroll_to=1323460 Thu, 11 Apr 2019 13:04:36 -0400 60% of men experience one trauma, 50% of women are likely to experience trauma, but 10% of women are likely to develop PTSD while men are 4% https://nowcomment.com/documents/136378?scroll_to=1317203 https://nowcomment.com/documents/136378?scroll_to=1317203 Fri, 05 Apr 2019 14:00:54 -0400 Definition of PTSD https://nowcomment.com/documents/136378?scroll_to=1317200 https://nowcomment.com/documents/136378?scroll_to=1317200 Fri, 05 Apr 2019 13:59:57 -0400 Anesthetic (1960s) then party drug "special K" then mental health treatment https://nowcomment.com/documents/136378?scroll_to=1317199 https://nowcomment.com/documents/136378?scroll_to=1317199 Fri, 05 Apr 2019 13:59:36 -0400 Most patients are ex-military with PTSD, very good with suicide problems https://nowcomment.com/documents/136378?scroll_to=1317197 https://nowcomment.com/documents/136378?scroll_to=1317197 Fri, 05 Apr 2019 13:59:07 -0400 Ketamine is a catalyst to BDNF production, low BDNF linked to depression https://nowcomment.com/documents/136379?scroll_to=1316298 https://nowcomment.com/documents/136379?scroll_to=1316298 Thu, 04 Apr 2019 16:40:29 -0400 Ketamine as an anesthetic for surgery, a party drug, and now an antidepressent https://nowcomment.com/documents/136379?scroll_to=1316281 https://nowcomment.com/documents/136379?scroll_to=1316281 Thu, 04 Apr 2019 16:34:19 -0400 Love this quote, validating mental health as a real health concern and raising the question as to why it is not taken as seriously. https://nowcomment.com/documents/136379?scroll_to=1316279 https://nowcomment.com/documents/136379?scroll_to=1316279 Thu, 04 Apr 2019 16:33:11 -0400 Author claims that ketamine works by boosting levels of a brain compound linked to depression https://nowcomment.com/documents/136379?scroll_to=1316278 https://nowcomment.com/documents/136379?scroll_to=1316278 Thu, 04 Apr 2019 16:32:36 -0400 Needs to be an easily broken down type of ketamine to allow for the conversion into (2R,64)-HNK. Ketamine not broken down easily doesn't do anything for depression https://nowcomment.com/documents/136380?scroll_to=1316276 https://nowcomment.com/documents/136380?scroll_to=1316276 Thu, 04 Apr 2019 16:31:29 -0400 Explanation of how the properties of ketamine are responsible for the relief of depression https://nowcomment.com/documents/136380?scroll_to=1316275 https://nowcomment.com/documents/136380?scroll_to=1316275 Thu, 04 Apr 2019 16:29:36 -0400 Not reversing depression effects by boosting, as her previous article said, rather breakdown properties responsible for the depression relief. What does it breakdown? https://nowcomment.com/documents/136380?scroll_to=1316274 https://nowcomment.com/documents/136380?scroll_to=1316274 Thu, 04 Apr 2019 16:29:02 -0400 With more and more research the FDA is slowly approving- Esketamine nasal spray recently FDA approved. New development since 2016 when the article was written. https://nowcomment.com/documents/136380?scroll_to=1316273 https://nowcomment.com/documents/136380?scroll_to=1316273 Thu, 04 Apr 2019 16:28:07 -0400 Certain chemicals found in the brain cause the interference of depression treatment, the scientists found. Could use this knowledge to model the treatment. https://nowcomment.com/documents/135444?scroll_to=1308541 https://nowcomment.com/documents/135444?scroll_to=1308541 Tue, 26 Mar 2019 16:41:50 -0400 Identified brain mechanisms responsible for interfering with treatment..this could potentially result in a lot of other discoveries relating to treatment-resistant depression above the ketamine study. https://nowcomment.com/documents/135444?scroll_to=1308530 https://nowcomment.com/documents/135444?scroll_to=1308530 Tue, 26 Mar 2019 16:40:22 -0400 Is ketamine necessarily the cause of the outbursts/suicidality? Was the treatment merely ineffective or could it have caused the behavioral outbursts? If so, should it be studied as a potentially "safe" treatment https://nowcomment.com/documents/135444?scroll_to=1308520 https://nowcomment.com/documents/135444?scroll_to=1308520 Tue, 26 Mar 2019 16:38:53 -0400 Plan to test how to make ketamine a sustainable depression treatment. https://nowcomment.com/documents/135444?scroll_to=1308519 https://nowcomment.com/documents/135444?scroll_to=1308519 Tue, 26 Mar 2019 16:37:07 -0400 Ketamine administered in small doses over a smaller period of time usually results in remittence. Have there been more studies with different combinations of infusion: larger infusions over shorter times or longer periods/smaller, more frequent infusions? https://nowcomment.com/documents/135444?scroll_to=1308518 https://nowcomment.com/documents/135444?scroll_to=1308518 Tue, 26 Mar 2019 16:36:27 -0400 Effective as a short term solution, but many patients experience quick remittence. Not much research on the safety and efficacy as a long term treatment. https://nowcomment.com/documents/135444?scroll_to=1308513 https://nowcomment.com/documents/135444?scroll_to=1308513 Tue, 26 Mar 2019 16:34:02 -0400 Grabs attention again by mentioning a change but not explaining what is going to happen. https://nowcomment.com/documents/133763?scroll_to=1295192 https://nowcomment.com/documents/133763?scroll_to=1295192 The readers can assume that the female aphids will find mates but the writer hasn't explained this yet. The reader is curious to know how when and why they will find mates so continues reading. The author set this up really smart to keep readers engaged. Tue, 19 Mar 2019 16:25:03 -0400 The writer grabs the reader's attention by relaying an unexpected turn of events in the aphids life, leaving the reader confused as to how that happens and why, and grabbing attention. Now the writer can get to the point of the essay https://nowcomment.com/documents/133763?scroll_to=1295179 https://nowcomment.com/documents/133763?scroll_to=1295179 Tue, 19 Mar 2019 16:22:31 -0400 Here the writer relates the information that was already given to the facts he's about to deliver. This way the reader, if they found the last paragraphs about aphid biology boring, are now curious about what else the author will be talking about. https://nowcomment.com/documents/133763?scroll_to=1295156 https://nowcomment.com/documents/133763?scroll_to=1295156 Tue, 19 Mar 2019 16:18:38 -0400 The analogy here, while gruesome, gives the reader a vivid visual that calls their attention back to the matter of the essay. It breaks up the scientific information with an example of the broader concept. https://nowcomment.com/documents/133763?scroll_to=1295153 https://nowcomment.com/documents/133763?scroll_to=1295153 Tue, 19 Mar 2019 16:17:40 -0400 This is a good way to engage interest. Mentioning the catholic faith allows readers to relate the concept to something that most of them are familiar with. Also breaking up the big scientific terms with this little reference re-engages readers. https://nowcomment.com/documents/133763?scroll_to=1295143 https://nowcomment.com/documents/133763?scroll_to=1295143 Tue, 19 Mar 2019 16:15:14 -0400 The writer initially grabs the readers attention by using the funny birds and bees saying about sex. This grabs the readers attention because its taking a serious scientific topic and making it more humorous and relatable to readers. https://nowcomment.com/documents/133763?scroll_to=1295102 https://nowcomment.com/documents/133763?scroll_to=1295102 Tue, 19 Mar 2019 16:06:53 -0400 SOLUTION https://nowcomment.com/documents/123145?scroll_to=1192312 https://nowcomment.com/documents/123145?scroll_to=1192312 Thu, 20 Dec 2018 12:23:33 -0500 Shifting focus from war to political diplomacy. Shifting the focus is propaganda, and done so because it works for those IN CONTROL OF THE MEDIA https://nowcomment.com/documents/123145?scroll_to=1192308 https://nowcomment.com/documents/123145?scroll_to=1192308 Thu, 20 Dec 2018 12:20:23 -0500 "The media only needs to give a reason for their message despite its validity in order forte to be accepted. (Cialdini 3) https://nowcomment.com/documents/123145?scroll_to=1192306 https://nowcomment.com/documents/123145?scroll_to=1192306 Thu, 20 Dec 2018 12:18:24 -0500 Shifting the talk in the media from something bad to something good to distract and to "serve the ideology they wish to spread" https://nowcomment.com/documents/123145?scroll_to=1192304 https://nowcomment.com/documents/123145?scroll_to=1192304 Thu, 20 Dec 2018 12:17:38 -0500 ENEMY AS BARBARIAN: portraying the enemy as uncivilized, in this case not advanced enough to responsibly handle nuclear weapons. https://nowcomment.com/documents/123145?scroll_to=1192300 https://nowcomment.com/documents/123145?scroll_to=1192300 Thu, 20 Dec 2018 12:14:27 -0500 Dehumanization: generalizing an entire group to their wrongdoings to spread fear and hatred https://nowcomment.com/documents/123145?scroll_to=1192285 https://nowcomment.com/documents/123145?scroll_to=1192285 Thu, 20 Dec 2018 12:11:20 -0500 Misusing quotes and taking things out of context to injure the other side https://nowcomment.com/documents/123145?scroll_to=1192284 https://nowcomment.com/documents/123145?scroll_to=1192284 Thu, 20 Dec 2018 12:10:21 -0500 Suggesting relationships between pakistan and the islamic territories, magnifying the danger by mentioning terrorism. https://nowcomment.com/documents/123145?scroll_to=1192282 https://nowcomment.com/documents/123145?scroll_to=1192282 Thu, 20 Dec 2018 12:08:58 -0500 Propaganda theory of similarity- differing regions are targeted by different messages. https://nowcomment.com/documents/123145?scroll_to=1192280 https://nowcomment.com/documents/123145?scroll_to=1192280 Thu, 20 Dec 2018 12:07:40 -0500 SOCIAL PROOF! Linking looser enemies to other definite enemies to provide a reason as to why they should be feared and hated. Justifications to QUICKLY form beliefs https://nowcomment.com/documents/123145?scroll_to=1192279 https://nowcomment.com/documents/123145?scroll_to=1192279 Thu, 20 Dec 2018 12:06:59 -0500 Humans are unsure of themselves, and since most are not experts in the topic of discussion, they look to others to agree with. LACK OF FREE THOUGHT due to natural self doubt https://nowcomment.com/documents/123145?scroll_to=1192277 https://nowcomment.com/documents/123145?scroll_to=1192277 Thu, 20 Dec 2018 12:05:47 -0500 How to analyze propaganda https://nowcomment.com/documents/123145?scroll_to=1192275 https://nowcomment.com/documents/123145?scroll_to=1192275 Thu, 20 Dec 2018 12:03:26 -0500 Even though the situation is the same, media portrays the sides differently due to not as strong ties. https://nowcomment.com/documents/123145?scroll_to=1192261 https://nowcomment.com/documents/123145?scroll_to=1192261 We then form our opinion of each nation based on the information that is fed to us, one positive and one negative. We then magnify different facts from each country and subdue others to further perpetuate their respective images. Thu, 20 Dec 2018 12:02:07 -0500 Propaganda is so normalized to us and can be used in the smallest most inconspicuous ways, making it hard to recognize https://nowcomment.com/documents/123145?scroll_to=1192254 https://nowcomment.com/documents/123145?scroll_to=1192254 Thu, 20 Dec 2018 11:57:35 -0500 **THE DUNE AFFECT https://nowcomment.com/documents/123145?scroll_to=1192252 https://nowcomment.com/documents/123145?scroll_to=1192252 Thu, 20 Dec 2018 11:56:26 -0500 All of the different types of media https://nowcomment.com/documents/123145?scroll_to=1192251 https://nowcomment.com/documents/123145?scroll_to=1192251 Thu, 20 Dec 2018 11:55:52 -0500 Using media to spread messages in order to deliberately injure another cause https://nowcomment.com/documents/123145?scroll_to=1192249 https://nowcomment.com/documents/123145?scroll_to=1192249 Thu, 20 Dec 2018 11:55:30 -0500 Messages from self mass communicated can reach a variety of audiences that take on a different meaning based on their own culture and circumstances https://nowcomment.com/documents/121988?scroll_to=1191828 https://nowcomment.com/documents/121988?scroll_to=1191828 Wed, 19 Dec 2018 20:28:57 -0500 Many different types of individualism https://nowcomment.com/documents/121988?scroll_to=1191820 https://nowcomment.com/documents/121988?scroll_to=1191820 Wed, 19 Dec 2018 16:34:44 -0500 Individualism definition in relation to the human psyche https://nowcomment.com/documents/121988?scroll_to=1191819 https://nowcomment.com/documents/121988?scroll_to=1191819 Wed, 19 Dec 2018 16:28:40 -0500 Individualism definition in relation to the human psyche https://nowcomment.com/documents/121988?scroll_to=1191818 https://nowcomment.com/documents/121988?scroll_to=1191818 Wed, 19 Dec 2018 16:28:09 -0500 "Individualism..a foundation of economic, political, and moral thinking" https://nowcomment.com/documents/121988?scroll_to=1191791 https://nowcomment.com/documents/121988?scroll_to=1191791 This is interesting because originally individualism was the basis of all thought, though in the context of mass media and globalization, the strive for individualism and the narcissistic tendencies of humans drove the weakening of the human personality, creating a more alike society Wed, 19 Dec 2018 12:48:23 -0500 Many opinions https://nowcomment.com/documents/121988?scroll_to=1191790 https://nowcomment.com/documents/121988?scroll_to=1191790 Wed, 19 Dec 2018 12:45:54 -0500 ****DIGITAL INCREASE IN THE POWER OF PUBLIC OPINION https://nowcomment.com/documents/122916?scroll_to=1190209 https://nowcomment.com/documents/122916?scroll_to=1190209 Tue, 18 Dec 2018 12:11:04 -0500 Digital Bill of Rights https://nowcomment.com/documents/122916?scroll_to=1190207 https://nowcomment.com/documents/122916?scroll_to=1190207 Encompasses free thought with the notion that the government could be spying on us and stealing our information. Tue, 18 Dec 2018 12:07:22 -0500 Solution/other opinion https://nowcomment.com/documents/122916?scroll_to=1190206 https://nowcomment.com/documents/122916?scroll_to=1190206 Honest Ads Act: standard rules, but would it be limiting? Tue, 18 Dec 2018 12:05:30 -0500 Additional opinion/solution https://nowcomment.com/documents/122916?scroll_to=1190204 https://nowcomment.com/documents/122916?scroll_to=1190204 Basically combating harsh and extreme content with distractions to other content, however problem arises when the question comes of WHO gets to be the "arbiters of truth". Tue, 18 Dec 2018 12:04:12 -0500 Counter Opinion https://nowcomment.com/documents/122916?scroll_to=1190203 https://nowcomment.com/documents/122916?scroll_to=1190203 Tue, 18 Dec 2018 12:02:28 -0500 Problem https://nowcomment.com/documents/122916?scroll_to=1190184 https://nowcomment.com/documents/122916?scroll_to=1190184 Propaganda dispersed, greatly influencing American politics, all through the seemingly good social media algorithms. Tue, 18 Dec 2018 10:46:44 -0500 Problem https://nowcomment.com/documents/122916?scroll_to=1190167 https://nowcomment.com/documents/122916?scroll_to=1190167 Algorithms created in effort to show content that the user would enjoy lead to increased polarization from opinion to opinion, and affirmation of the other party's downfall. Tue, 18 Dec 2018 10:42:17 -0500 Solution https://nowcomment.com/documents/121976?scroll_to=1190152 https://nowcomment.com/documents/121976?scroll_to=1190152 The author recognizes a need to abolish partisan gerrymandering, as this often paves the way for super extremist candidates. Were gerrymandering outlawed, or even mandating neutral gerrymandering officials could re-establish a more moderate system of candidates Tue, 18 Dec 2018 10:32:47 -0500 Solution https://nowcomment.com/documents/121976?scroll_to=1190144 https://nowcomment.com/documents/121976?scroll_to=1190144 The author proposes that local parties would need to collaborate to strategically choose attractive and less extremist candidates to maximize national gain. Tue, 18 Dec 2018 10:29:37 -0500 Main problem https://nowcomment.com/documents/121976?scroll_to=1190133 https://nowcomment.com/documents/121976?scroll_to=1190133 The main problem discussed in the article seems to be that the entire country has been polarized, largely due to the fact that local elections have gained national importance and people from all over find the need to weigh in to keep their side on top. Wed, 19 Dec 2018 21:16:16 -0500